Fibrosarcoma (fibroblastic sarcoma) is a
malignant tumor derived from
fibrous connective tissue and characterized by immature
The tumor may present different degrees of
differentiation: low grade (differentiated), intermediate malignancy and
high malignancy (anaplastic). Depending on this differentiation, tumor cells may
resemble mature fibroblasts (spindle-shaped), secreting
collagen, with rare
mitoses. These cells are arranged in short fascicles which split and merge,
giving the appearance of "fish bone". Poorly differentiated tumors consist in
more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical
mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous
vessels lacking endothelial cells) favors the bloodstream metastasizing.
Fibrosarcoma in dogs and cats
Fibrosarcoma occurs most frequently in the the mouth in dogs. The tumor is
locally invasive, and reoccurs often following surgery.
chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone
tumor in dogs.
In cats, fibrosarcoma occurs on the skin. It also the most common
- Ettinger, Stephen J.;Feldman, Edward C.(1995).Textbook of Veterinary
Internal Medicine(4th ed.). W.B. Saunders Company.
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