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Malignant Histiocytosis

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Malignant histiocytosis is a hereditary disease found in the Bernese Mountain Dog characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Symptoms include cough, loss of appetite, weight loss, and depression. Diagnosis requires a biopsy. Treatment with chemotherapy has been used with some success. Because of the rapid progression of the disease, the prognosis is poor.


  • Ettinger, Stephen J.;Feldman, Edward C.(1995).Textbook of Veterinary Internal Medicine(4th ed.). W.B. Saunders Company. ISBN 0-7216-6795-3

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